54: Hematopoietic cell transplantation-comorbidity index (HCT-CI)

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was desi...

Hematopoietic Cell Transplantation-Specific Comorbidity Index: A New Tool for Risk Assessment Before Allogeneic HCT

Pediatric Hematopoietic Stem Cell Transplantation

The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

Hematopoietic cell transplantation comorbidity index predicts transplantation outcomes in pediatric patients.

Quantifying the risk of hematopoietic cell transplantation (HCT)-related mortality for pediatric patients is challenging. The HCT-specific comorbidity index (HCT-CI) has been confirmed as a useful tool in adults, but has not yet been validated in children. We conducted a retrospective cohort study of 252 pediatric patients undergoing their first allogeneic HCT between January 2008 and May 2009....

Recent Advances in Allogeneic Hematopoietic Stem Cell Transplantation (hct)

T he number of allogeneic haemopoietic-cell transplantations (HCT) continues to rise, with more than 25,000 procedures undertaken annually. Several changes in our transplantation practice have contributed to decreased severity of GVHD and organ toxicity, which resulted in improvement in patient outcomes. These changes include the use of reduced intensity conditioning, less toxic conditioning/im...